The discontinuation of Windows Server 2008 R2 patch deployment means you will stop seeing new patches every month. As long as vendors continue support for Windows Server 2008 R2, third-party patches, required software, and most Worklets will continue to apply and be relevant.
If your organization has a need to continue using Windows Server R2, Microsoft offers Extended Security Updates on a per server basis. For more information, see their FAQ: https://www.microsoft.com/en-us/cloud-platform/extended-security-updates
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